Ann,, Ph.D. Revill, Ph.D.

Understanding the cellular and synaptic components that make up a neural circuit is key to unlocking the mysteries of how these components generate behaviour. We use the breathing circuit that controls the upper airway as a model system to address these fundamental research questions.



Breathing is a robust and adaptable rhythmic behaviour that maintains blood gases at appropriate values in the face of multiple perturbations including state (sleep vs. wakefulness), posture, development and maturation, and changing metabolic requirements (for example, during exercise). Breathing furthermore must be coordinated with other oromotor behaviours such as chewing, swallowing, and speaking. We are particularly interested in how the neurochemicals that modulate neural excitability can influence neuronal behaviour in this network.



To address these research questions, we use a rodent model. We employ a rhythmic slice preparation for in vitro electrophysiology recordings including extracellular whole nerve recording and whole-cell recording (see image). We also perform anatomical experiments using viral transneuronal tracing, immunohistochemistry, and light and confocal microscopy. Students can expect to develop their own research project, and are encouraged to present their findings at local and national meetings.
Respiratory neurophysiology
Neuromodulation of neural networks