Layla Al-Nakkash, Ph.D.
Chair
Physiology
- ChairPhysiology
- 623-572-3662
RESEARCH INTERESTS
Our overal lab goal is to understand and identify the mechanisms of action of dietary genistein on the gut-brain axis in various murine models of clinically relevant diseases: cystic fibrosis, diabetes (ob/ob and high fat/high sugar-fed), and Alzheimer's.
We routinely use the following techniques: Ussing chamber electrophysiology, gastrointestinal motility and contractility, histology, western blot, pcr.
Effects of genistein on intestinal epithelial function
Cystic fibrosis, Obesity and Diabetes
Alzheimer's disease
We routinely use the following techniques: Ussing chamber electrophysiology, gastrointestinal motility and contractility, histology, western blot, pcr.
Effects of genistein on intestinal epithelial function
Cystic fibrosis, Obesity and Diabetes
Alzheimer's disease
GRANTS
- EXTRAMURAL RESEARCH GRANTAssessment of Metabolomic Pathways Involved in the Brain-intestinal Axis in Western Diet Induced Alzheimer's PathologyArizona Alzheimer's Consortium1 Jul 2024 - 30 Jun 2025People funded by this grant:
- Al-Nakkash L
- EXTRAMURAL RESEARCH GRANTMetabolic Intervention of Alzheimer's Disease: Ketone Bodies as a Potential Strategy to Improve Energy Metabolism in the Aging BrainArizona Alzheimer's Consortium1 Jul 2024 - 30 Jun 2025People funded by this grant:
- Shim M,
- Broderick T,
- Al-Nakkash L
- EXTRAMURAL RESEARCH GRANTGeroscience Approach to Alzheimer's Disease: Mitigation of Cellular Senescence by Intermittent FastingArizona Alzheimer's Consortium1 Jul 2023 - 30 Jun 2024People funded by this grant:
- Shim M,
- Al-Nakkash L,
- Broderick T
- EXTRAMURAL RESEARCH GRANTInvolvement of the Brain-muscle Axis in Western Diet Induced Alzheimer's PathologyArizona Alzheimer's Consortium1 Jul 2023 - 30 Jun 2024People funded by this grant:
- Al-Nakkash L,
- Shim M,
- Broderick T
- EXTRAMURAL RESEARCH GRANTWestern Diet Induced Alzheimer's Pathology: Assessment of the Brain-Gut-Bone AxisArizona Alzheimer's Consortium1 Jul 2022 - 30 Jun 2023People funded by this grant:
- Al-Nakkash L,
- Broderick T,
- Shim M,
- Lee S
- MWU INTRAMURAL GRANTInfluence of Intermittent Fasting on IntestinePeople funded by this grant:
- Al-Nakkash L
- MWU INTRAMURAL GRANTReversibility of Diet-induced Liver Steatosis and FibrosisPeople funded by this grant:
- Al-Nakkash L