Midwestern University homepage
Photo of Minsub Shim, Ph.D.

Minsub Shim, Ph.D.

Associate Professor

Biochemistry and Molecular Genetics

  • Associate Professor
    Biochemistry and Molecular Genetics

BIO

I received my Ph.D. degree in Molecular and Cellular Toxicology from the North Carolina State University (NCSU), where I studied the role and regulation of bZIP transcription factor CCAAT/enhancer binding protein-alpha (C/EBPa) in a mouse model of skin carcinogenesis.

During my post-doctoral training at the National Institute of Environmental Health Sciences (NIEHS), my research was focused on cyclooxygenase-2 (COX2) signaling. I have developed a highly versatile COX2 transgenic mouse model using Cre-loxP technology. Using this mouse model, I have demonstrated that COX2 signaling interferes with skeletal development. I also found that COX2 positively regulates p53 expression, which has not been previously reported. Additionally, for the first three years of my post-doctoral research, I studied the regulation and function of Non-Steroidal Anti-Inflammatory Drug (NSAIDs)-Activated Gene-1 (NAG-1, also known as GDF-15), which is a member of transforming growth factor-beta (TGFb) superfamily. I have been awarded the NIH Pathway to Independence Award (K99/R00) entitled " The role of COX-2 in skeletal development and osteoarthritis" .

Currently, our studies are focused on COX2 and prostanoid receptors, which are downstream mediators of COX2. We have demonstrated that COX2 regulates doxorubicin (DOX)-induced p53 expression through modulation of oxidative stress. In addition, our recent study using a novel COX2 transgenic mouse model revealed the previously unrecognized role of COX2 in aging. My laboratory also has reported that prostaglandin E2 receptor subtype 2 (EP2) regulates p38 kinase activation and that prostaglandin F2 alpha receptor (FP) stimulates BMP signaling and chondrocyte differentiation. We also recently reported that Jagged-2, a NOTCH ligand, plays an important role in the survival of colorectal cancer cells in response to chemotherapeutic agents including DOX.

My laboratory is familiar with the techniques such as bioimaging, histopathological/immunohistochemical analysis, viral expression (adenovirus, adeno-associated virus, and lentivirus), RNAi (siRNA and shRNA), CRISPR/Cas9, and primary cell culture from mouse tissues. Mouse models of human disease are also being used. N/A

MIDWESTERN UNIVERSITY APPOINTMENTS

  • Associate Professor
    College of Graduate Studies - Arizona

DEGREES

  • Ph.D.
    North Carolina State University, USA2003
  • M.S.
    Yonsei, USA1992
  • B.S.
    Yonsei, USA1990

ACADEMIC DEGREE PROGRAM

  • Doctor of Osteopathic Medicine (D.O.)

CAMPUS

  • Glendale